chronic kidney disease — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T14002	12-Ketodeoxycholic acid		Endogenous Metabolite
	12-Ketodeoxycholic acid, a bile acid and kidney metabolite, serves as a detectable marker for kidney injury [1].		Endogenous Metabolite
T7802	M1001		HIF/HIF Prolyl-Hydroxylase , HIF
	M1001 is a HIF-2α agonist.		HIF/HIF Prolyl-Hydroxylase , HIF
T9022	AZD9977	AZD 9977	Glucocorticoid Receptor
	AZD9977 is a novel, selective modulator of mineralocorticoid receptor .		Glucocorticoid Receptor
T4583	PFI-2 hydrochloride	(R)-PFI-2 hydrochloride,PFI-2 HCl	Histone Methyltransferase
	PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2.		Histone Methyltransferase
T21395	Finerenone	BAY948862,BAY-948862,BAY94-8862,BAY 94-8862,BAY-94-8862,BAY 948862	Glucocorticoid Receptor
	Finerenone (BAY-948862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment of chronic heart failure. Finerenone (BAY-948862...		Glucocorticoid Receptor
T6666	Sevelamer Carbonate		Others
	Sevelamer carbonate is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion.		Others
T1987	PFI-2	PFI2,PFI 2,(R)-PFI-2	Histone Methyltransferase
	PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.		Histone Methyltransferase
T13591	Calcium polystyrene sulfonate	Poly(styrenesulfonic acid) calcium salt	Others
	Calcium polystyrene sulfonate (Poly(styrenesulfonic acid) calcium salt) is an ion-exchange resin. Calcium polystyrene sulfonate reduces blood levels of potassium and can be used for research on the treatment of hyperkale...		Others
T21977	P-Cresyl sulfate		Others
	p-Cresyl Sulfate is a major uremic toxin found in the blood of patients with chronic kidney disease (CKD), derived from the metabolites of tyrosine and phenylalanine in the liver.		Others
T30479	Bis-T-23	Bis T-23,Bis-T 23,AG1717	HIV Protease
	Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV...		HIV Protease
T13604	CDDO-dhTFEA		Others , NF-κB , Nrf2
	CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expressi...		Others , NF-κB , Nrf2
T4938	Potassium 1H-indol-3-yl sulfate	Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate	AhR , Endogenous Metabolite
	Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) has recently emerged as a pathophysiological regulator of imm...		AhR , Endogenous Metabolite
T28222	5-Hydroxy-1-methylhydantoin	HD-003,HD003,NZ419,NZ-419,HD 003,NZ 419	Bradykinin Receptor
	5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to con...		Bradykinin Receptor
T32193	Iron sorbitex	Jectofer,Yectofer,Iron Sorbitol,HSDB 1967,Astra 1572
	Iron Sorbitex is used for the treatment of Iron Sorbitex deficiency anemia in patients with chronic kidney disease. Iron Sorbitex can be used as an Iron Sorbitex replacement product used for the treatment of Iron Sorbite...
T39410	Zevaquenabant	(S)-MRI-1867
	Zevaquenabant ((S)-MRI-1867), a dual cannabinoid CB1 receptor and inducible NOS (iNOS) antagonist, is orally bioavailable and peripherally restricted. It effectively mitigates obesity-induced chronic kidney disease (CKD)...
T38419	Difelikefalin	CR-845,FE-202845
	Difelikefalin (CR-845; FE-202845) is a peripherally restricted, selective agonist of the kappa opioid receptor (KOR). It exhibits anti-inflammatory properties and holds promise for modulating pruritus in conditions assoc...
T60937	TRPC5-IN-1
	TRPC5-IN-1 is a TRPC5 inhibitor active in various animal models of chronic kidney disease.
T73332	BI-685509
	BI-685509 is a potent and orally active sGC activator. BI-685509 restores cyclic guanosine monophosphate (cGMP) and improves functionality of nitric oxide (NO) pathways. BI-685509 can be used in research of chronic kidne...
T69294	UK‑396082
	UK-396082 is a potent inhibitor of thrombin-activated fibrinolytic inhibitor (TAFI), enhancing plasmin activity while concurrently reducing levels of the extracellular matrix (ECM). This compound is valuable for research...
T80220	OK2		EGFR
	OK2, a specific inhibitor of the CCN2/EGFR interaction, effectively disrupts this interaction by binding to the CT domain of CCN2. It holds potential for use in research pertaining to kidney fibrosis and chronic kidney d...		EGFR